Furoquinolines with Antiplatelet Aggregation Activity from Leaves of Melicope confusa

Keh-Shaw Chen; Ya-Ling Chang; Che-Ming Teng; Chieh-Fu Chen; Yang-Chang Wu*

doi:10.1055/s-0029-1243116

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Planta Med 2000; 66(1): 80-81
DOI: 10.1055/s-0029-1243116

Letter

Furoquinolines with Antiplatelet Aggregation Activity from Leaves of Melicope confusa

Keh-Shaw Chen¹ , Ya-Ling Chang² , Che-Ming Teng² , Chieh-Fu Chen³ , Yang-Chang Wu³ ^, ⁴ ^,*

¹Ta-Jen Pharmaceutical Junior College, Ping Tung Hsien, Taiwan
²Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
³National Research Institute of Chinese Medicine, Taipei, Taiwan
⁴Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, Taiwan

Further Information

Publication History

Received: May 6, 1999

Accepted: June 12, 1999

Publication Date:
24 November 2009 (online)

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Abstract

Using antiplatelet aggregation as a guide for fractionation, four furoquinoline-type alkaloids, confusameline (1), skimmianine (2), kokusaginine (3), and O-methylconfusameline (4), were isolated from the leaves of Melicope confusa. All compounds showed significant antiplatelet aggregation activity.

References

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Prof. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung 807

Taiwan

Email: yachwu@cc.kmc.edu.tw

Fax: +886-7-3114773

Phone: +886-7-3121101 ext. 2197