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DOI: 10.1055/s-0029-1242614
Neue Entwicklungen in der perioperativen (Radio-)Chemotherapie des lokal fortgeschrittenen Rektumkarzinoms
Publication History
Publication Date:
30 June 2010 (online)
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Zusammenfassung
Die neoadjuvante 5-Fluorouracil-basierte Radiochemotherapie stellt einen Standard in der präoperativen Therapie des lokal fortgeschrittenen Rektumkarzinoms dar. In der folgenden Übersicht sollen aktuelle Daten zu einer Modifikation bzw. Intensivierung der 5-FU-basierten Radiochemotherapie vorgestellt werden. Des Weiteren wird die Rolle der Induktionschemotherapie sowie die Rolle der adjuvanten Chemotherapie nach stattgehabter neoadjuvanter Radiochemotherpaie und Tumorresektion kritisch diskutiert.
Summary
5-fluorouracil-based chemoradiotherapy represents a standard neoadjuvant treatment for patients with locally advanced rectal cancer. This review discusses recent data on the modification and intensification of 5-fluorouracil based chemoradiotherapy. Moreover, the role of induction chemotherapy as well as the role of adjuvant chemotherapy after neoadjuvant chemoradiotherapy and tumor resection is critically discussed.
Schlüsselwörter
Adjuvante Chemotherapie - Bevacizumab - Cetuximab - Chemoradiotherapie - Induktionschemotherapie - Oxaliplatin - Rektumkarzinom
Keywords
Adjuvant chemotherapy - bevacizumab - cetuximab - chemoradiotherapy - induction chemotherapy - oxaliplatin - rectal cancer
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Korrespondenzadresse
Prof. Dr. med. Ralf-Dieter Hofheinz
TagesTherapieZentrum (TTZ) am Interdisziplinären Tumorzentrum Mannheim (ITM)
Universitätsmedizin Mannheim
Ruprecht-Karls-Universität Heidelberg
Theodor-Kutzer Ufer 1 – 3
68167 Mannheim
Email: ralf.hofheinz@umm.de