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DOI: 10.1055/s-0029-1234107
© Georg Thieme Verlag KG Stuttgart · New York
Improved Metabolic Control After 12-Week Dietary Intervention with Low Glycaemic Isomalt in Patients with Type 2 Diabetes Mellitus
Publication History
received 30.01.2009
accepted 13.07.2009
Publication Date:
21 August 2009 (online)
![](https://www.thieme-connect.de/media/hmr/200912/lookinside/thumbnails/10.1055-s-0029-1234107-1.jpg)
Abstract
The polyol isomalt (Palatinit®) is a very low glycaemic sugar replacer. The effect of food supplemented with isomalt instead of higher glycaemic ingredients like sucrose and/or starch hydrolysates on metabolic control in patients with type 2 diabetes was examined in this open study. Thirty-three patients with type 2 diabetes received a diet with foods containing 30 g/d isomalt instead of higher-glycaemic carbohydrates for 12 weeks. Metformin and/or thiazolidindiones were the only concomitant oral antidiabetics allowed during the study. Otherwise, the participants maintained their usual diet during the test phase, but were instructed to refrain from additional sweetened foods. Before start, after 6 weeks and 12 weeks (completion of the study), blood samples were taken and analysed for clinical routine parameters, metabolic, and risk markers. Thirty-one patients completed the study. The test diet was well accepted and tolerated. After 12 weeks, significant reductions were observed for: glycosylated haemoglobin, fructosamine, fasting blood glucose, insulin, proinsulin, C-peptide, insulin resistance (HOMA-IR), and oxidised LDL (an atherosclerosis risk factor). In addition, significant lower nonesterified fatty acid concentrations were found in female participants. Routine blood measurements and blood lipids remained unchanged. The substitution of glycaemic ingredients by isomalt and the consequent on reduction of the glycaemic load within otherwise unchanged diet was accompanied by significant improvement in the metabolic control of diabetes. The present study is in agreement with findings of previous reported studies in human subjects demonstrating beneficial effects of low glycaemic diets on glucose metabolism in patients with diabetes mellitus type 2.
Key words
glycaemic index - glycaemic load - carbohydrate metabolism
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Correspondence
I. Holub
University of Würzburg
Department of Medicine II
Division of Gastroenterology
Grombühlstraße 12
Haus Auvera
97080 Würzburg
Germany
Phone: + 49/931/201 458 87
Fax: + 49/931/201 458 29
Email: holub_i@medizin.uni-wuerzburg.de