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Semin Respir Crit Care Med 2009; 30(3): 253-261
DOI: 10.1055/s-0029-1222439
© Thieme Medical Publishers

Obesity Hypoventilation Syndrome

Kenneth I. Berger1 , Roberta M. Goldring1 , David M. Rapoport1
  • 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, NYU/Bellevue Medical Center, New York, New York
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Publication History

Publication Date:
18 May 2009 (online)

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ABSTRACT

The term obesity hypoventilation syndrome (OHS) refers to the combination of obesity and chronic hypercapnia that cannot be directly attributed to underlying cardiorespiratory disease. Despite a plethora of potential pathophysiological mechanisms for gas exchange and respiratory control abnormalities that have been described in the obese, the etiology of hypercapnia in OHS has been only partially elucidated. Of particular note, obesity and coincident hypercapnia are often associated with some form of sleep disordered breathing (apnea/hypopnea or sustained periods of hypoventilation). From a conceptual point of view, even transient reductions of ventilation from individual sleep disordered breathing events must produce acute hypercapnia during the period of low ventilation. What is less clear, however, is the link between these transient episodes of acute hypercapnia and the development of chronic sustained hypercapnia persisting into wakefulness. A unifying view of how this comes about is presented in the following review. In brief, our concept is that chronic sustained hypercapnia (as in obesity hypoventilation) occurs when the disorder of ventilation that produces acute hypercapnia interacts with inadequate compensation (both during sleep and during the periods of wakefulness); neither alone is sufficient to fully explain the final result. The following discussion will amplify on both the potential reasons for acute hypercapnia in the obese and on what is known about the failure of compensation that must occur in these subjects.

KEYWORDS

Obesity - obesity hypoventilation syndrome - hypercapnia - sleep disordered breathing

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Kenneth I BergerM.D. 

NYU School of Medicine, Rm. RR 108, 550 First Ave.

New York, NY 10016

Email: kenneth.berger@nyumc.org