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Synfacts 2010(7): 0745-0745  
DOI: 10.1055/s-0029-1220019
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Zolpidem

Contributor(s): Philip Kocienski
N. Chernyak, V. Gevorgyan*
University of Illinois at Chicago, USA
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Publication History

Publication Date:
22 June 2010 (online)

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Significance

Zolpidem is a widely prescribed hypnotic for the short-term treatment of insomnia. It acts by binding to GABAA receptors at the same location as benzodiazepines. Alpidem, an anxio­lytic drug that has been withdrawn from the market owing to liver damage, was also synthesized by the same route.