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Synfacts 2010(6): 0622-0622
DOI: 10.1055/s-0029-1219851
DOI: 10.1055/s-0029-1219851
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Formal Synthesis of Diazonamide A
C.-K. Mai, M. F. Sammons, T. Sammakia*
University of Colorado, Boulder, USA
Further Information
Publication History
Publication Date:
20 May 2010 (online)
Significance
Diazonamide A was isolated from colonial ascidian Diazona angulata in 1991. The main synthetic challenge presented by diazonamide A is the hindered quaternary center at C10. To date, three total syntheses have been developed: one by the Nicolaou group, one by Harran and co-workers, and a formal synthesis by Magnus and co-workers.