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Synfacts 2010(5): 0582-0582  
DOI: 10.1055/s-0029-1219678
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Bromine-Lithium Exchange on Cyano-Substituted Arenes Using Microreactors

Contributor(s): Paul Knochel, Tobias Thaler
A. Nagaki, H. Kim, H. Usutani, C. Matsuo, J.-i. Yoshida*
Kyoto University, Japan
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Publication History

Publication Date:
22 April 2010 (online)

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Significance

The dynamics of microflow systems allow the performance of reactions that ­cannot be carried out under standard conditions. A bromine-lithium exchange on arenes bearing sensitive cyano groups could be successfully implemented with a microflow system.