Synfacts 2010(5): 0589-0589  
DOI: 10.1055/s-0029-1219661
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Dehydrative Pd/Cu-Catalyzed Coupling of Heterocycles with Terminal Alkynes

Contributor(s): Paul Knochel, Andrei Gavryushin
F.-A. Kang*, J. C. Lanter, C. Cai, Z. Sui, W. V. Murray
Johnson & Johnson Pharmaceutical Research and Development, Spring House, USA
Further Information

Publication History

Publication Date:
22 April 2010 (online)

Significance

The first chemoselective direct ­dehydrative cross-coupling of tautomerizable ­heterocycles with terminal alkynes via bimetallic Pd/Cu catalysis is reported. It uses readily available starting materials and is efficient for a number of various N-heterocycles and alkynes being ­especially suitable for substrates with sensitive groups.