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Synfacts 2010(4): 0429-0429  
DOI: 10.1055/s-0029-1219619
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Synthesis of β-Aryloxy Alcohols via Dynamic Kinetic Resolution

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
W.-J. Bai, J.-H. Xie, Y.-L. Li, S. Liu, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

The authors report a highly dia­stereo- and enantioselective hydrogenation of α-aryloxy-substituted ketones to afford β-aryloxy alcohols. Their method was further used in the synthesis of a non-steroidal glucocorticoid modulator.