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Synfacts 2010(4): 0437-0437
DOI: 10.1055/s-0029-1219616
DOI: 10.1055/s-0029-1219616
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Metal-Controlled Reversal of Enantio-selectivity in the Alkylation of Indoles
Y. Liu, D. Shang, X. Zhou, Y. Zhu, L. Lin, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
Further Information
Publication History
Publication Date:
22 March 2010 (online)
Significance
The catalytic system described allows efficient access to chiral building blocks, such as tryptophan derivatives. Slight modification of the ligand and changing the metal center allows for reversal of enantioselectivity with impressive yields and high ee values.