Decarboxylative Benzylation of Diphenyl-glycinate Imines

W. H. Fields; J. J. Chruma

doi:10.1055/s-0029-1219600

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Synfacts 2010(4): 0461-0461
DOI: 10.1055/s-0029-1219600

Metal-Mediated Synthesis

Decarboxylative Benzylation of Diphenyl-glycinate Imines

Contributor(s): Paul Knochel, Tobias Thaler
W. H. Fields, J. J. Chruma*
University of Virginia, Charlottesville, USA

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Publication History

Publication Date:
22 March 2010 (online)

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Significance

A general procedure for the palladium-catalyzed decarboxylative benzylation of diphenylglycinate imines has been developed. The reaction could be applied to a broad range of substrates tolerating heteroaryl moieties, bromo, cyano, and ester functionalities.