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Synfacts 2010(4): 0469-0469
DOI: 10.1055/s-0029-1219592
DOI: 10.1055/s-0029-1219592
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
A New Ligand for Copper-Catalyzed Cross-Coupling of Heterocycles and Phenols
M. S. Kabir, M. Lorenz, O. A. Namjoshi, J. M. Cook*
University of Wisconsin-Milwaukee, USA
Further Information
Publication History
Publication Date:
22 March 2010 (online)
Significance
The authors report the use of 2-pyridin-2-yl-1H-benzimidazole as a new, efficient, and versatile bidentate ligand for copper-catalyzed formation of vinylic C-N and C-O bonds. Vinylic bromides or iodides can both be used and the reaction affords the corresponding vinylated phenols or N-heterocycles in excellent yields and under full retention of stereochemistry of the double bond.