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Synfacts 2010(4): 0391-0391  
DOI: 10.1055/s-0029-1219447
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Syntheses of Isodomoic Acids G and H

Contributor(s): Steven V. Ley, Matthew O’Brien
S. E. Denmark*, J. H.-C. Liu, J. M. Muhuhi
University of Illinois, Urbana, USA
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

Isodomoic acids G and H were isolated from the red algae Chondria armata and belong to the family of neuroexitatory kainoid amino acids which are important research tools in neuroscience and medicinal chemistry. Notable steps in the syntheses are a carbonylative silylcarbacyclization and a silicon-based sp²-sp² coupling.