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Synfacts 2010(3): 0370-0370
DOI: 10.1055/s-0029-1219287
DOI: 10.1055/s-0029-1219287
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Reaction of Thiols with Aryl Iodides with CuO on Mesoporous Silica
C.-K. Chen, Y.-W. Chen, C.-H. Lin, H.-P. Lin*, C.-F. Lee*
National Chung Hsing University, Taichung and National Cheng Kung University, Tainan, Taiwan
Further Information
Publication History
Publication Date:
18 February 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201003/lookinside/thumbnails/10.1055-s-0029-1219287-1.jpg)
Significance
CuO on mesoporous silica was prepared by hydrothermal treatment of a mixture of gelatin, Cu(NO3)2×2.5H2O, and Na2SiO3 in water, followed by calcination (eq. 1). The CuO on mesoporous silica catalyzed the coupling reaction of thiols with aryl iodides in the presence of Cs2CO3 in DMSO or dioxane to give the corresponding aryl sulfides in 66-97% yield (25 examples, eq. 2).