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Synfacts 2010(3): 0372-0372  
DOI: 10.1055/s-0029-1219283
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Gold-Catalyzed Reduction of Nitro Compounds with CO and H2O

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
L. He, L.-C. Wang, H. Sun, J. Ni, Y. Cao*, H.-Y. He, K.-N. Fan
Fudan University, Shanghai, P. R. of China
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

An efficient and selective reduction of nitro compounds with CO and H2O was achieved by using gold nanoparticles supported on TiO2. The reaction of nitro compounds (1 mmol) in EtOH (or DMF)-H2O (15 mL, 2:1 v/v) with Au/TiO2 under CO led to the corresponding amines (24 examples). Both the nature of the support and the particle size of gold had a strong influence on the catalytic activity. Gold nanoparticles with a diameter of about 1.9 nm supported on TiO2 showed the highest activity.