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Synfacts 2010(2): 0159-0159  
DOI: 10.1055/s-0029-1219114
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Multicomponent Synthesis of Trisubstituted Imidazoles

Contributor(s): Victor Snieckus, Johnathan Board
M. Adib*, S. Ansari, S. Feizi, J. A. Damavandi, P. Mirzaei
University of Tehran, Teacher Training University, Tehran and Shahid Beheshti University, Tehran, Iran
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

Reported is the four-component synthesis of trisubstituted imidazoles involving the reaction of benzaldehydes, 2-bromoacetophenones, primary amines, and ammonium acetate. The reaction uses no added solvents and proceeds efficiently in short reaction times. A number of potential mechanisms are possible, one of which is shown by the authors. This example mechanism effectively demonstrates one of the main advantages of multicomponent reactions; the formation and use of reactive intermediates that would not usually be possible to access or isolate.

Book: M. R. Grimmett, In Science of Synthesis, Vol. 12; R. Neier, Ed.; Georg Thieme Verlag: ­Stuttgart, New York, 2002, 325-528.