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Synfacts 2009(10): 1113-1113  
DOI: 10.1055/s-0029-1217913
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Allylation of Carbamates

Contributor(s): Hisashi Yamamoto, Pingfan Li
D. J. Weix, D. Marković , M. Ueda, J. F. Hartwig*
University of Illinois, Urbana, USA
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Direct allylation of carbamates with achiral allylic carbonates is realized through iridium catalysis to afford very useful chiral allylic amines with various carbamate-protecting groups in excellent yields and enantiomeric ratios. The undesired linear products can be readily separated through chromatography to afford pure branched products.