Download PDF
Synfacts 2009(9): 1022-1022  
DOI: 10.1055/s-0029-1217692
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Practical Arene Hydrogenation by Heterogeneous Catalysts

Contributor(s): Paul Knochel, Andrei Gavryushin
T. Maegawa, A. Akashi, K. Yaguchi, Y. Iwasaki, M. Shigetsura, Y. Monguchi, H. Sajiki*
Gifu Pharmaceutical University, Japan
Further Information

Publication History

Publication Date:
21 August 2009 (online)

    Permissions and Reprints

Significance

Reduction of arenes and hetarenes into the corresponding saturated derivatives is an important method for the synthesis of functionalized cyclohexanes as well as pharmacologically important heterocycles like piperidine. The authors developed a practical and simple protocol for the hydrogenation of arenes and hetarenes ­under relatively mild conditions, suitable for a broad variety of functionalized substrates.