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Synthesis 2009(12): 2035-2039
DOI: 10.1055/s-0029-1216805
DOI: 10.1055/s-0029-1216805
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Strecker-Type Reaction Catalyzed by Carboxylic Acids in Aqueous Media
Weitere Informationen
Publikationsverlauf
Received
16 December 2008
Publikationsdatum:
12. Mai 2009 (online)


Abstract
Carboxylic acid catalyzed Strecker-type reactions were successfully carried out by simply mixing aldehydes, amines, tributyltin cyanide and carboxylic acid in aqueous media at room temperature, to afford α-aminonitriles in high yields.
Key words
Strecker reaction - α-aminonitriles - tributyltin cyanide - carboxylic acid - aqueous media