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Synfacts 2009(6): 0636-0636
DOI: 10.1055/s-0029-1216716
DOI: 10.1055/s-0029-1216716
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Addition of Allyl Cyanide to Ketones
R. Yazaki, N. Kumagai*, M. Shibasaki*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
25 May 2009 (online)
![](https://www.thieme-connect.de/media/synfacts/200906/lookinside/thumbnails/10.1055-s-0029-1216716-1.jpg)
Significance
Ketones are inherently less reactive to nucleophilic addition than their aldehydes counterparts. Moreover, the enantioselective addition of various nucleophile further compounds the possible problems encountered due to the steric similarities in ketones relative to that of aldehydes. In this report, the authors have shown an efficient copper-catalyzed reaction that provides useful tertiary alcohols with a Z-configured unsaturated nitrile.