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Synfacts 2009(5): 0564-0564
DOI: 10.1055/s-0029-1216582
DOI: 10.1055/s-0029-1216582
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Generation of Fluorine Containing Quaternary Carbon Centers
X. Han, J. Luo, C. Liu, Y. Lu
National University of Singapore, Singapore
Further Information
Publication History
Publication Date:
22 April 2009 (online)
Significance
An enantioselective generation of fluorinated quaternary stereogenic centers adjacent to tertiary stereocenters via a Michael reaction of fluorinated nucleophiles with nitroolefins is reported. High enantioselectivities were achieved with several aryl and alkyl nitrooelfins as Michael acceptor as well as different aryl ketones.