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Synfacts 2009(5): 0578-0578  
DOI: 10.1055/s-0029-1216558
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Alcohol Oxidation and Aldol Condensation with Gold Nanoparticles

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
S. Kim, S. W. Bae, J. S. Lee, J. Park*
Pohang University of Science and Technology, Republic of Korea
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Gold nanoparticles Au/AlO(OH) were prepared by mixing HAuCl4 hydrate, Al(Os-Bu)3, and Pluronic P123 in EtOH (eq. 1). Au/AlO(OH) catalyzed the oxidation of primary and secondary alcohols to give the corresponding ­carbonyl products in up to 99% yield (eq. 2, 16 examples). When the reaction of benzyl alcohol with Au/AlO(OH) was carried out in the presence of ketones, the corresponding dehydrative aldol products (Claisen-Schmit products) were obtained in up to 90% yield (eq. 3, 4 examples).