Thorac Cardiovasc Surg 2009; 57(5): 281-285
DOI: 10.1055/s-0029-1185564
Original Cardiovascular

© Georg Thieme Verlag KG Stuttgart · New York

Aspirin Resistance after CABG

S. Sanioglu1 , S. Tetik2 , O. Sokullu1 , H. Deniz1 , N. Aydemir1 , M. Yilmaz1 , I. Y. Arslan1 , F. Bilgen1
  • 1Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research , Hospital, Istanbul, Turkey
  • 2Department of Biochemistry, Marmara University, Faculty of Pharmacy, Istanbul, Turkey
Further Information

Publication History

received October 28, 2008

Publication Date:
23 July 2009 (online)

Abstract

Background: Temporary aspirin resistance can occur during the post-CABG period. If the factors causing resistance can be identified, the incidence of early graft occlusions can also be minimized. Methods: 25 elective CABG cases were enrolled in the study. The platelet count, mean platelet volume, the C-reactive protein level, lipid profile, blood urea nitrogen (BUN), and creatinine levels were identified one day before the operation and on the 1st, 5th and 10th postoperative days. Optical aggregometry was used for the evaluation of aspirin response. The patients were divided into two groups: those with aspirin resistance and those with no aspirin resistance. Results: The rate of postoperative aspirin resistance was found to be 60 %. No significant difference was found when the preoperative and operative data of the two groups were compared. It was found that the rapid changes observed in the postoperative platelet counts and the C-reactive protein levels were similar. Conclusion: Aspirin resistance is encountered during the early postoperative period in the majority of patients undergoing CABG. None of the factors studied were found to be causative for resistance formation. Further studies are required to clarify this entity.

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Dr. Soner Sanioglu

Department of Cardiovascular Surgery
Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital

Tibbiye cad, Haydarpasa

34420 Istanbul

Turkey

Phone: + 90 21 64 44 52 57

Fax: + 90 21 63 69 88 11

Email: sanioglu@gmail.com