Antioxidant and Hepatoprotective Activities of Thai Mango Seed Kernel Extract

Abstract

Three polyphenolic principles, 1,2,3,4,6-penta-O-galloyl-β‐D-glucopyranose (PGG), methyl gallate (MG), and gallic acid (GA), were isolated from the ethanolic extract of seed kernels of Thai mango (MSKE) (Mangifera indica L. cv. “Fahlun”) and quantified using a TLC scanning densitometric method. The MSKE and its isolates were investigated by studying their antioxidant capacities using four different methods, by determining their in vitro anti-inflammatory activities, and by evaluating their hepatoprotective potential against liver injury in rats induced by carbon tetrachloride (CCl₄). The hepatoprotective effect of MSKE is clearly supported by its polyphenolic nature of the main principle, PGG, which exhibited potent antioxidant and anti-inflammatory activities.

Key words

Mangifera indica L. - Anacardiaceae - pentagalloylglucopyranose - antioxidant - anti‐inflammatory - hepatoprotective activity

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