Outbreak of Parainfluenza Virus Type 3 in a Neonatal Intensive Care Unit

ABSTRACT

Parainfluenza virus (PIV) causes > 30% of all acute respiratory infections in infants and children and is second only to respiratory syncytial virus as a cause of lower respiratory tract infection. However in the neonatal intensive care unit (NICU), PIV outbreaks are highly uncommon. This case report describes an outbreak of 3 cases of PIV type 3 in a regional NICU.

KEYWORDS

Parainfluenza - type 3 - virus - viral - NICU - neonate - outbreak - ribavirin

REFERENCES

• 1 Stoll B. Infections of the neonatal infant. In: Behrman R Nelson Textbook of Pediatrics. Philadelphia; WB Saunders 2004: 624-640
• 2 Parija S, Marrie T. Parainfluenza Virus. eMedicine. February 1, 2007. Available at: http://www.emedicine.com/med/TOPIC1733.HTM Accessed July 18, 2008
• 3 Human Parainfluenza Viruses. CDC web site. June 06, 2006. Available at: http://www.cdc.gov/ncidod/dvrd/revb/respiratory/hpivfeat.htm Accessed July 18, 2008
• 4 Henrickson K J. Parainfluenza viruses.  Clin Microbiol Rev. 2003;  16 242-264
• 5 Moisiuk S E, Robson D, Klass L et al.. Outbreak of parainfluenza virus type 3 in an intermediate care neonatal nursery.  Pediatr Infect Dis J. 1998;  17 49-53
• 6 Singh-Naz N, Willy M, Riggs N. Outbreak of parainfluenza virus type 3 in a neonatal nursery.  Pediatr Infect Dis J. 1990;  9 31-33
• 7 Light Diagnostics Respiratory DFA Viral Screening & Identification Kit .Catalogue No. 3137, May 2007. Available at: http://www.millipore.com/techpublications/tech1/74k5d8 Accessed December 3, 2008
• 8 American Academy of Pediatrics .Parainfluenza viral infections. In: Pickering LK Red Book: 2006 Report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, IL; American Academy of Pediatrics 2006: 479-481
• 9 Ansari S A, Springthorpe V S, Sattar S A, Rivard S, Rahman M. Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14.  J Clin Microbiol. 1991;  29 2115-2119
• 10 Glezen W P, Frank A L, Taber L H, Kasel J A. Parainfluenza virus type 3: seasonality and risk of infection and reinfection in young children.  J Infect Dis. 1984;  150 851-857
• 11 Panasiuk A, Wysocka J, Maciorkowska E et al.. Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis.  World J Gastroenterol. 2005;  11 7661-7665
• 12 Sweetman SC Ribavirin. Martindale: The Complete Drug Reference. Available at: http://www.medicinescomplete.com/mc/ Accessed November 30, 2008
• 13 McIntosh K, Kurachek S C, Cairns L M, Burns J C, Goodspeed B. Treatment of respiratory viral infection in an immunodeficient infant with ribavirin aerosol.  Am J Dis Child. 1984;  138 305-308
• 14 Sparrelid E, Ljungman P, Ekelöf-Andström E et al.. Ribavirin therapy in bone marrow transplant recipients with viral respiratory infections.  Bone Marrow Transplant. 1997;  19 905-908
• 15 Chakrabarti S, Collingham K E, Holder K, Oyaide S, Pillay D, Milligan D W. Parainfluenza virus type 3 infections in hematopoetic stem cell transplant recipients: response to ribavirin therapy.  Clin Infect Dis. 2000;  31 1516-1518