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Synfacts 2009(5): 0468-0468  
DOI: 10.1055/s-0028-1088171
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ent-EBC-23

Contributor(s): Philip Kocienski, Zofia Komsta
L. Dong, V. A. Gordon, R. L. Grange, J. Johns, P. G. Parsons, A. Porzelle, P. Reddell, H. Schill, C. M. Williams*
University of Queensland, Queensland Institute of Medical Research, Brisbane, and EcoBiotics Ltd., Yungaburra, Australia
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

EBC-23 was extracted from the fruit of Cinnamomum laubati, an Australian tropical rainforest plant from the family of Lauraceae. The compound showed antitumor activity towards a spectrum of human cancer cell lines (among them melanoma MM96L, breast carcinoma MCF7 and prostate cancer DU145) and is a strong potential candidate for the treatment of refractory solid tumors.