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Synfacts 2009(3): 0314-0314
DOI: 10.1055/s-0028-1087710
DOI: 10.1055/s-0028-1087710
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Hf(IV)-Catalyzed Chemoselective Thioacetalization and Transthioacetalization
Y.-C. Wu, J. Zhu*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
Further Information
Publication History
Publication Date:
19 February 2009 (online)
Significance
Hf(OTf)4 is reported as a powerful catalyst for thioacetalization and transthioacetalization. Sterically hindered substrates react efficiently and many sensitive functionalities are tolerated. The reaction proceeds in a chemoselective manner with a preference for aromatic aldehydes over benzylic aldehydes and ketones.