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Synfacts 2009(1): 0087-0087  
DOI: 10.1055/s-0028-1087458
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd/BrettPhos: A Highly Active Catalyst for
C-N Cross-Coupling Reactions

Contributor(s): Paul Knochel, Andreas J. Wagner
B. P. Fors, D. A. Watson, M. R. Biscoe, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

The new biaryl phosphine ligand BrettPhos is shown to be an extremely active ligand for Pd-catalyzed amination of aryl mesylates or chlorides. The respective secondary amines are obtained in very good to excellent yields.