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Synfacts 2009(1): 0086-0086
DOI: 10.1055/s-0028-1087452
DOI: 10.1055/s-0028-1087452
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd(II)-Catalyzed Hiyama Cross-Coupling Using a Water-Soluble Ligand System
S.-N. Chen, W.-Y. Wu, F.-Y. Tsai*
National Taipei University of Technology, Taipei, Taiwan
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
A Pd(NH3)2Cl2/cationic bipyridyl catalytic system is able to efficiently catalyze the cross-coupling reaction of aryl bromides with arylsiloxanes in water under aerobic conditions in the presence of NaOH to afford biaryls in good to excellent yields. After extraction, the residual aqueous phase can be used several times with only a minor decrease in catalyst activity.