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Synfacts 2009(1): 0055-0055  
DOI: 10.1055/s-0028-1087402
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Carbene Insertion into
Si-H Bonds

Contributor(s): Mark Lautens, Jane Panteleev
Y.-Z. Zhang, S.-F. Zhu, L.-X. Wang, Q.-L. Zhou*
, Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Carbene insertion into silicone-­hydrogen bonds is a well-established process ­pioneered by M. P. Doyle, C. J. Moody and co-workers (Tetrahedron Lett. 1996, 38, 7631). The majority of the developments in this area, how­ever, have been dominated by rhodium catalysis. The authors report a copper-catalyzed protocol where, by utilizing a new spiro-diimine ligand, chiral silanes are formed in high yield and enantio­selectivities.