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Synfacts 2009(1): 0038-0038  
DOI: 10.1055/s-0028-1087271
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

NIR Squaraine Dye Detects Aminothiols

Contributor(s): Timothy M. Swager, Jose M. Lobez
S. Sreejith, K. P. Divya, A. Ajayaghosh*
National Institute for Inter-disciplinary Science and Technology, Trivandrum, India
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

It is believed that the amount of ­thiol-containing amino acids in blood is related to several human diseases. The authors propose a squaraine based dye (1) to probe these molecules. Upon addition of the analyte to the squaraine core, extended π-conjugation between the two satellite conjugated molecules is broken, and fluorescence is detected in the visible range.