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Synfacts 2009(1): 0011-0011  
DOI: 10.1055/s-0028-1087240
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of α-Tocopherol

Contributor(s): Philip Kocienski
K. Liu, A. Chougnet, W.-D. Woggon*
Universität Basel, Switzerland
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

The synthesis of α-tocopherol (vitamin E) depicted features an organocatalytic domino oxa-Michael-aldol reaction to construct the chromanol ring in D. Seven diaryl prolinol organocatalysts were evaluated with C (30 mol%) giving the highest yield and diastereomeric ratios.