Download PDF
Neuropediatrics 1978; 9(2): 127-130
DOI: 10.1055/s-0028-1085417
Original article

© 1978 by Thieme Medical Publishers, Inc.

Leukocyte Docosahexaenoic Acid in Juvenile Form of Ceroid-Lipofuscinosis

R. K. Pullarkat, V. K. Patel, H. Brockerhoff
  • New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten Island, NY 10314 and Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202
Further Information

Publication History

1977

1977

Publication Date:
18 November 2008 (online)

    Permissions and Reprints

Leukocyte glycerolipid fatty acid compositions were determined in four patients of juvenile form of neuronal ceroid-lipofuscinosis (Battens disease), their parents and age-matched controls. A 54 to 93% reduction in docosahexaenoic acid (22:6, n-3) was noted in patient leukocytes. The parents also showed reduction in docosahexaenoic acid content, but to a lesser degree. The levels of linolenic family (n-6) polyunsaturated fatty acids were unchanged suggesting that the metabolic defect in this disease is specific to the linolenic family (n-3) of fatty acids.

Neuronal ceroid-lipofuscinosis - Balten disease - Docosahexaenoic acid Leukocyte

      >