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Synfacts 2008(11): 1131-1131  
DOI: 10.1055/s-0028-1083421
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Macbecin I

Contributor(s): Philip Kocienski, Stewart Eccles
J. K. Belardi, G. C. Micalizio*
Yale University, New Haven, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

Macbecin I belongs to the ansamycin family of antibiotics that display a multitude of activities such as antitumor, antimicrobial and ­antifungal properties. The synthesis of macbecin I hinges on a metal-mediated reductive coupling to join the two fragments D and H.