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Synfacts 2008(11): 1139-1139  
DOI: 10.1055/s-0028-1083409
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Bryostatin Analogues

Contributor(s): Philip Kocienski
P. A. Wender*, B. A. DeChristopher, A. J. Schrier
Stanford University, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

Bryostatin 1 is a potent antineoplastic agent that restores apoptotic function, stimulates the immune system and reverses multidrug resistance through its modulation of protein kinase C (PKC). It also enhances cognition and memory in animals. Only 1.5 mg of bryostatin 1 is needed for an eight-week clinical treatment cycle. The Wender group’s synthesis of the simpler analogue depicted features an exceptionally efficient Prins-driven macrocyclization that is one of the most complex examples of any Prins cyclization.