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Synfacts 2008(11): 1238-1238  
DOI: 10.1055/s-0028-1083400
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Preparation of Propargylamines via Multicomponent Reaction with Cu(I) Zeolites

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
M. K. Patil, M. Keller, B. M. Reddy, P. Pale*, J. Sommer*
Indian Institute of Chemical Technology, Hyderabad, India and Université L. Pasteur, Strasbourg, France
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

A copper zeolite Cu(I)-USY was prepared by treatment of H-USY, which was generated from NH4-USY upon heating (550 ˚C), with CuCl at 350 ˚C for three days. The three-component coupling reaction of amines 1, aldehydes 2 and terminal alkynes 3 was carried out in the presence of 7 mol% Cu of Cu(I)-USY to give the corresponding propargylamines 4 in 0-95% yield (18 examples). The catalyst was recycled four times without significant loss of catalytic activity.