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Synthesis 2009(5): 767-774
DOI: 10.1055/s-0028-1083366
DOI: 10.1055/s-0028-1083366
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Facile Synthetic Route towards Substituted Thieno[3,2-e]indoles
Further Information
Received
28 August 2008
Publication Date:
11 February 2009 (online)
Publication History
Publication Date:
11 February 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200905/lookinside/thumbnails/10.1055-s-0028-1083366-1.jpg)
Abstract
A number of substituted thieno[3,2-e]indoles have been prepared in high yields via a tetrabutylammonium fluoride mediated cyclization of 5-acetamido-4-ethynylbenzothiophenes, which, in turn, are easily accessible from the corresponding 4-iodobenzothiophenes. This method presents a viable alternative to the traditionally used Fischer indolization procedures.
Key words
thienoindoles - palladium - cyclizations - fused-ring systems - tetrabutylammonium fluoride
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