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Synthesis 2008(21): 3423-3428
DOI: 10.1055/s-0028-1083177
DOI: 10.1055/s-0028-1083177
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Multicomponent Domino Cyclization-Oxidative Aromatization on a Bifunctional Pd/C/K-10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines
Further Information
Received
23 May 2008
Publication Date:
16 October 2008 (online)
Publication History
Publication Date:
16 October 2008 (online)
![](https://www.thieme-connect.de/media/synthesis/200821/lookinside/thumbnails/10.1055-s-0028-1083177-1.jpg)
Abstract
A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.
Key words
Pd/C/K-10 montmorillonite - solid acid - microwave irradiation - bifunctional catalysis - green chemistry - pyridines
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