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Synfacts 2009(1): 0088-0088  
DOI: 10.1055/s-0028-1078449
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

In-Catalyzed Direct Cyanation of Alcohols using TMSCN

Contributor(s): Paul Knochel, Andreas J. Wagner
G. Chen, Z. Wang, J. Wu, K. Ding*
Shanghai institute of organic chemistry, P. R. of China
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

In this work, a convenient and efficient synthesis of α-aryl nitriles is presented by reaction of alcohols with TMSCN under the catalysis of indium salts. A variety of benzylic alcohols can be thereby converted into the corresponding nitriles in good to excellent yields.