Total Syntheses of Antimalarial Cyclic Tetrapeptides: Koshidacins A and B via Olefin Cross-Metathesis Reactions

Abstract

In this study, we present the first total syntheses of koshidacins A and B, antiplasmodial cyclic tetrapeptides from fungus, by assembling the side chain in late stage through olefin cross-metathesis. Additionally, the two diastereoisomers 8,9-epi-koshidacin A and 9-epi-koshidacin B were also synthesized by our synthetic route.

Key words

koshidacin A - koshidacin B - total synthesis - cross-metathesis - antiplasmodial - cyclic tetrapeptides

Publication History

Received: 24 January 2025

Accepted after revision: 18 February 2025

Accepted Manuscript online:
18 February 2025

Article published online:
02 April 2025

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