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Exp Clin Endocrinol Diabetes 2024; 132(11): 631-641
DOI: 10.1055/a-2399-1174
Article

Dihydromyricetin Improves High Glucose-Induced Dopaminergic Neuronal Damage by Activating AMPK-Autophagy Signaling Pathway

Qi Li‡
1   Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)
2   Department of Pathology, Yuebei People’s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, China (Ringgold ID: RIN159372)
,
Zhenjiang Song‡
1   Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)
,
Liting Peng
1   Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)
,
Shuidong Feng
3   Department of Social Medicine and Health Management, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)
,
Kebin Zhan
4   Department of Neurology, The Second Affiliated Hospital, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)
,
Hongyan Ling 
1   Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)
› Author AffiliationsSupported by: Hengyang Science and Technology Board 202330046219
Supported by: Health Commission of Hunan Province C202303076198
Supported by: Natural Science Foundation of Hunan Province 2021JJ30595,2022JJ50161
› Further Information
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Abstract

Introduction In recent years, a growing number of clinical and biological studies have shown that patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing Parkinson’s disease (PD). Prolonged exposure to hyperglycemia results in abnormal glucose metabolism, which in turn causes pathological changes similar to PD, leading to selective loss of dopaminergic neurons in the compact part of the substantia nigra. Dihydromyricetin (DHM) is a naturally occurring flavonoid with various biological activities including antioxidant and hepatoprotective properties. In this study, the effect of DHM on high glucose-induced dopaminergic neuronal damage was investigated.

Methods The potential modulatory effects of DHM on high glucose-induced dopaminergic neuronal damage and its mechanism were studied.

Results DHM ameliorated high glucose-induced dopaminergic neuronal damage and autophagy injury. Inhibition of autophagy by 3-methyladenine abrogated the beneficial effects of DHM on high glucose-induced dopaminergic neuronal damage. In addition, DHM increased levels of p-AMP-activated protein kinase (AMPK) and phosphorylated UNC51-like kinase 1. The AMPK inhibitor compound C eliminated DHM-induced autophagy and subsequently inhibited the ameliorative effects of DHM on high glucose-induced dopaminergic neuronal damage.

Discussion DHM ameliorates high glucose-induced dopaminergic neuronal damage by activating the AMPK-autophagy pathway.

Keywords

dihydromyricetin - AMPK - autophagy - dopaminergic neuronal - high glucose


Publication History

Received: 23 April 2024

Accepted after revision: 21 August 2024

Accepted Manuscript online:
21 August 2024

Article published online:
26 September 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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