Organocatalytic Approaches Towards the Synthesis of Asymmetric Tetrahydroquinoline (THQ) Derivatives

Abstract

1,2,3,4-Tetrahydroquinolines (THQs) are present in molecules with significant biological importance and pharmaceuticals with diverse biological activities. Various synthetic routes have been developed to tetrahydroquinolines, such as the hydrogenation of quinolines, domino reactions, intramolecular cyclization, and notably, the Povarov reaction. Organocatalysts are small, chiral organic molecules that can successfully catalyze organic transformations. This review examines the use of organocatalysts in the asymmetric synthesis of tetrahydroquinoline derivatives using aminocatalysis, NHC catalysis, and H-bonding catalysis covering the literature between 2000 and early 2024.

1 Introduction

2 Aminocatalysis

3 NHC Catalysis

4 H-Bonding Catalysis

5 Miscellaneous

6 Conclusion

Key words

organocatalysis - tetrahydroquinolines - aminocatalysis - NHC catalysis - H-bonding catalysis - Povarov reaction

Publication History

Received: 31 May 2024

Accepted after revision: 30 July 2024

Accepted Manuscript online:
30 July 2024

Article published online:
25 September 2024

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