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Synthesis 2024; 56(20): 3142-3146
DOI: 10.1055/a-2359-8893
DOI: 10.1055/a-2359-8893
paper
Flow Chemistry
Efficient Flow Synthesis of Glycidyl Ether Using BuSnCl3 as a Mild Lewis Acid
We wish to thank the Japan Society for the Promotion of Science (JSPS) for funding through a Grant-in-Aid for Scientific Research (B) (No. 19H02722) and Scientific Research (C) (No. 24K08433).
Abstract
A ring-opening protocol of epichlorohydrin with 2-ethylhexanol was investigated for the synthesis of the corresponding chlorohydrin ether. BuSnCl3 proved to be an efficient mild Lewis acid catalyst, yielding the product with high selectivity. A scalable flow synthesis was achieved by modifying the flow setup. The flow synthesis of the corresponding glycidyl ether from the chlorohydrin ether was also carried out in an efficient manner by using the basic treatment.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2359-8893.
- Supporting Information
Publication History
Received: 13 April 2024
Accepted after revision: 03 July 2024
Accepted Manuscript online:
03 July 2024
Article published online:
24 July 2024
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