Epilepsie-Update

ZUSAMMENFASSUNG

Die letzten Jahre waren geprägt von der Etablierung neuer, innovativer Diagnose- und Therapieverfahren im Bereich der Epileptologie. Es sind beispielsweise Systeme zur Ultra-Langzeit-EEG-Registrierung verfügbar. Die Frühtherapie einer refraktären Epilepsie wird zunehmend durch die Entwicklung neuer Therapiemethoden verbessert. Neurostimulationsverfahren werden weiterentwickelt und neue Technologien wurden eingeführt. Vielversprechend sind auch die synergistischen Effekte der Neurostimulation in Kombination mit bestimmten Wirkmechanismen anfallsunterdrückender Medikamente im Rahmen der Neuromodulation. Dieser Überblick beleuchtet all diese Entwicklungen der letzten anderthalb Jahre.

ABSTRACT

The last few years have been characterized by the establishment of new, innovative diagnostic and therapeutic procedures in the field of epileptology. Systems for ultra-long-term EEG registration are emerging. The early treatment of refractory epilepsy is increasingly being addressed through the development of new therapeutic methods. Neurostimulation procedures are being further developed and new technologies are being introduced. The synergistic effects of neurostimulation in combination with certain mechanisms of action of seizure-suppressing drugs in the context of neuromodulation are also promising. This overview highlights all these developments over the last year and a half.

Schlüsselwörter

Epilepsie - Neurostimulation - Ultra-Langzeit-EEG - Lennox-Gastaut-Syndrom - Post-Stroke-Epilepsie

Key words

Epilepsy - neurostimulation - ultra-long-term EEG - Lennox-Gastaut syndrome - post-stroke epilepsy

Publication History

Article published online:
17 July 2024

• Literatur

• 1 Pujar S, Cross JH. Diagnosis of Lennox-Gastaut syndrome and strategies for early recognition.. Expert Rev Neurother 2024; 24 (04) 383-389
• 2 Winter Y, Uphaus T, Sandner K. et al Efficacy and safety of antiseizure medication in post-stroke epilepsy.. Seizure 2022; 100: 109-114
• 3 Winter Y, Sandner K, Vieth T. et al Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study.. CNS Drugs 2023; 37 (10) 929-936
• 4 Winter Y, Sandner K, Vieth T. et al Eslicarbazepine acetate for the treatment of status epilepticus.. Epileptic Disord 2023; 25 (02) 142-149
• 5 Winter Y, Sandner K, Glaser M. et al Synergistic effects of vagus nerve stimulation and antiseizure medication.. J Neurol 2023; 270 (10) 4978-4984
• 6 Sauer V, Glaser M, Ellwardt E. et al Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy.. Epilepsy Behav 2024; 150: 109562
• 7 Schulze-Bonhage A, Hirsch M, Knake S. et al EASEE Study Group. Focal Cortex Stimulation With a Novel Implantable Device and Antiseizure Outcomes in 2 Prospective Multicenter Single-Arm Trials.. JAMA Neurol 2023; 80 (06) 588-596
• 8 Viana PF, Remvig LS, Duun-Henriksen J. et al Signal quality and power spectrum analysis of remote ultra long-term subcutaneous EEG.. Epilepsia 2021; 62 (08) 1820-1828