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Horm Metab Res 2024; 56(07): 504-508
DOI: 10.1055/a-2316-9124
Original Article: Endocrine Care

Low Concentration of Lipoprotein(a) is an Independent Predictor of Incident Type 2 Diabetes

Wenhao Liu
1   Cardiology, Zibo Central Hospital, Zibo, China (Ringgold ID: RIN117906)
,
Guanzhao Zhang
1   Cardiology, Zibo Central Hospital, Zibo, China (Ringgold ID: RIN117906)
,
Zifan Nie
1   Cardiology, Zibo Central Hospital, Zibo, China (Ringgold ID: RIN117906)
,
Xiangfeng Guan
2   Cardiology, Shandong Second Medical University, Weifang, China (Ringgold ID: RIN372527)
,
Tingting Sun
2   Cardiology, Shandong Second Medical University, Weifang, China (Ringgold ID: RIN372527)
,
Xiaodong Jin
3   Geriatric Medicine, Zibo Central Hospital, Zibo, China (Ringgold ID: RIN117906)
,
Bo Li
1   Cardiology, Zibo Central Hospital, Zibo, China (Ringgold ID: RIN117906)
› Author AffiliationsSupported by: National Natural Science Foundation of China 81700321
Supported by: Natural Science Foundation of Shandong Province ZR2020MH025
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Abstract

The aim of the study was to assess the association between lipoprotein(a) [Lp(a)] concentration and incident type 2 diabetes. A meta-analysis of qualified studies on the relationship of low levels of Lp(a) concentration with incident type 2 diabetes was conducted. PubMed and Cochrane libraries were searched for randomized controlled trials containing data on events. Seven randomized trials with 227178 subjects were included in this analysis. We found an inverse association of the levels of Lp(a) concentration with risk of type 2 diabetes with approximately 37% lower relative risk in the group with the highest concentration compared with group with the lowest concentration. The current available evidence from prospective studies suggests that there is an inverse association between the levels of Lp(a) concentration and risk of type 2 diabetes, with a higher risk of type 2 diabetes at low levels of Lp(a) concentration. Therefore, we believe that the low levels of Lp(a) concentration is an independent predictor of incident type 2 diabetes.

Keywords

lipoprotein(a) - meta-analysis - inverse association - type 2 diabetes


Publication History

Received: 08 June 2023

Accepted after revision: 25 April 2024

Article published online:
21 May 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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