Intensivmedizin up2date 2024; 20(02): 141-160
DOI: 10.1055/a-2271-4113
Allgemeine Intensivmedizin

Nicht invasive Beatmung und High-Flow-Therapie: Lebensretter nicht nur bei COPD

Felix Bronisch
,
Thomas Gude
,
F. Joachim Meyer

Die nicht invasive Beatmung (NIV) und die nasale High-Flow-Therapie (HFNC) sind aus dem Instrumentarium der Intensiv- und Notfallmedizin nicht mehr wegzudenken. Richtig angewendet, können sie dem Patienten mit respiratorischer Insuffizienz eine Intubation ersparen und seine Prognose entscheidend verbessern.

Kernaussagen
  • Um die Vorteile der nicht invasiven Beatmung (NIV) voll ausschöpfen zu können, ist neben der richtigen Indikationsstellung die individuelle Anpassung des Verfahrens an den Patienten und sein Krankheitsbild entscheidend.

  • Essenziell sind die Auswahl und Anpassung des Interfaces sowie die differenzierte Einstellung der Beatmungsparameter.

  • Die Beatmung mit High-Flow-Nasenkanüle (HFNC) bietet im hypoxisch bedingten Versagen eine wertvolle Alternative zur NIV; im hyperkapnischen Versagen kann sie die NIV oft sinnvoll ergänzen, z. B. in NIV-Pausen.

  • Beide Verfahren erfordern eine engmaschige Überprüfung des Therapieerfolgs.

  • Bei Therapieversagen ist eine rechtzeitige Intubation indiziert (s. hierzu auch [Abb. 3]).



Publication History

Article published online:
04 June 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Dalziel J. On sleep and apparatus for promoting artificial respiration. Br Assoc Adv Sci 1838; 1: 127
  • 2 Brochard L, Isabel D, Piquet J. et al. Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask. N Engl J Med 1990; 323: 1523-1530
  • 3 Macintyre N. Physiologic effects of noninvasive ventilation. Respir Care 2019; 64: 617-628
  • 4 Chadda K, Annane D, Hart N. et al. Cardiac and respiratory effects of continuous positive airway pressure and noninvasive ventilation in acute cardiac pulmonary edema. Crit Care Med 2002; 30: 2457-2461
  • 5 Masip J, Peacock WF, Price S. et al. Indications and practical approach to non-invasive ventilation in acute heart failure. Eur Heart J 2018; 39: 17-25
  • 6 Westhoff M, Neumann P, Geiseler J. et al. S2k-Leitlinie Nichtinvasive Beatmung als Therapie der akuten respiratorischen Insuffizienz. AWMF-Registernr. 020–004. Accessed December 15, 2023 at: https://register.awmf.org/de/leitlinien/detail/020–004
  • 7 Kluge S, Janssens U, Welte T. S3-Leitlinie Empfehlungen zur Stationären Therapie von Patienten mit COVID-19. Pneumologie 2021; 75: 88-112
  • 8 Rochester DF, Braun NMT, Arora NS. Respiratory muscle strength in chronic obstructive pulmonary disease. Am Rev Respir Dis 1979; 119: 151-154
  • 9 Meyer FJ. Assessment and management of hyperinflation in the intensive care unit. Pneumologe 2017; 14: 11-19
  • 10 Osadnik CR, Tee VS, Carson-Chahhoud KV. et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2017; (07) CD004104
  • 11 Stefan MS, Nathanson BH, Higgins TL. et al. Comparative effectiveness of noninvasive and invasive ventilation in critically ill patients with acute exacerbation of chronic obstructive pulmonary disease. Crit Care Med 2015; 43: 1386-1394
  • 12 Plant PK, Owen JL, Elliott MW. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet 2000; 355: 1931-1935
  • 13 Diaz GG, Alcaraz AC, Talavera JCP. et al. Noninvasive positive-pressure ventilation to treat hypercapnic coma secondary to respiratory failure. Chest 2005; 127: 952-960
  • 14 Conti G, Antonelli M, Navalesi P. et al. Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial. Intensive Care Med 2022; 28: 1701-1707
  • 15 Barbé F, Togores B, Rubí M. et al. Noninvasive ventilatory support does not facilitate recovery from acute respiratory failure in chronic obstructive pulmonary disease. Eur Respir J 1996; 9: 1240-1245
  • 16 Burns KEA, Meade MO, Premji A. et al. Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure. Cochrane Database Syst Rev 2013; (12) CD004127
  • 17 Nava S, Gregoretti C, Fanfulla F. et al. Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients. Cirt Care Med 2005; 33: 2465-2470
  • 18 Sharp JT, Griffith JT, Bunelli IL. et al. Ventilatory mechanics in pulmonary edema in man. J Clin Investig 1958; 37: 111-117
  • 19 Hauge A, Bo G, Waaler BA. Interrelations between pulmonary liquid volumes and lung compliance. J Appl Physiol 1975; 37: 608-614
  • 20 Lenique F, Habis M, Lofaso F. et al. Ventilatory and hemodynamic effects of continuous positive airway pressure in left heart failure. Am J Respir Crit Care Med 1997; 155: 500-505
  • 21 Gray A, Goodacre S, Newby DE. et al. Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 2008; 359: 142-151
  • 22 Berbenetz N, Wang Y, Brown J. et al. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev 2019; (04) CD005351
  • 23 Cabrini L, Landoni G, Oriani A. et al. Noninvasive ventilation and survival in acute care settings: a comprehensive systematic review and metaanalysis of randomized controlled trials. Crit Care Med 2015; 43: 880-888
  • 24 Vital FMR, Ladeira MT, Atallah AN. et al. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev 2013; (05) CD005351
  • 25 Mariani J, Macchia A, Belziti C. et al. Noninvasive ventilation in acute cardiogenic pulmonary edema: a meta-analysis of randomized controlled trials. J Card Fail 2011; 17: 850-859
  • 26 Weng CL, Zhao YT, Liu QH. et al. Meta-analysis: noninvasive ventilation in acute cardiogenic pulmonary edema. Ann Intern Med 2010; 152: 590-600
  • 27 Potts JM. Noninvasive positive pressure ventilation: effect on mortality in acute cardiogenic pulmonary edema: a pragmatic meta-analysis. Pol Arch Med Wewn 2009; 119: 349-353
  • 28 Confalonieri M, Potena A, Carbone G. et al. Acute respiratory failure in patients with severe community-acquired pneumonia: a prospective randomized evaluation of noninvasive ventilation. Am J Respir Crit Care Med 1999; 160: 1585-1591
  • 29 Carrillo A, Gonzales-Diaz G, Ferrer M. et al. Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure. Intensive Care Med 2012; 38: 458-466
  • 30 Stefan MS, Priya A, Pekow PS. et al. The comparative effectiveness of noninvasive and invasive ventilation in patients with pneumonia. J Crit Care 2018; 43: 190-196
  • 31 Carron M, Freo U, Zorzi M. et al. Predictors of failure of noninvasive ventilation in patients with severe community-acquired pneumonia. J Crit Care 2010; 25: 540.e9-540.e14
  • 32 Nicolini A, Ferraioli G, Ferrari-Bravo M. et al. Early non-invasive ventilation treatment for respiratory failure due to severe community-acquired pneumonia. Clin Respir J 2016; 10: 98-103
  • 33 Murad A, Li PZ, Dial S. et al. The role of noninvasive positive pressure ventilation in community-acquired pneumonia. J Crit Care 2015; 30: 49-54
  • 34 Estopa R, Marti AT, Kastanos N. et al. Acute respiratory failure in severe hematologic disorders. Crit Care Med 1984; 12: 26-28
  • 35 Blot F, Guiguet M, Nitenberg G. et al. Prognostic factors for neutropenic patients in an intensive care unit: respective roles of underlying malignancies and acute organ failures. Eur J Cancer 1997; 33: 1031-1037
  • 36 Dumas G, Chevret S, Lemiale V. et al. Survival in immunocompromised patients ultimately requiring invasive mechanical ventilation: a pooled individual patient data analysis. Am J Respir Crit Care Med 2021; 204: 187-196
  • 37 Hilbert G, Gruson D, Vargas F. et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001; 344: 481-487
  • 38 Antonelli M, Conti G, Bufi M. et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA 2000; 283: 235-241
  • 39 Lemiale V, Mokart D, Resche-Rigon M. et al. Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial. JAMA 2015; 314: 1711-1719
  • 40 Frat JP, Ragot S, Girault C. et al. Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial. Lancet Respir Med 2016; 4: 646-652
  • 41 Dumas G, Chevret S, Lemiale V. et al. Oxygenation/non-invasive ventilation strategy and risk for intubation in immunocompromised patients with hypoxemic acute respiratory failure. Oncotarget 2018; 9: 33682-33693
  • 42 Rathi NK, Haque SA, Nates R. et al. Noninvasivepositive pressure ventilation vs invasive mechanical ventilation as first-line therapy for acute hypoxemic respiratory failure in cancer patients. J Crit Care 2017; 39: 56-61
  • 43 Barreto LM, Ravetti CG, Athaide TB. et al. Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes. J Intensive Care 2020; 8: 68
  • 44 Oczenski W. Atmen-Atemhilfen: Atemphysiologie und Beatmungstechnik. Stuttgart: Thieme; 2008
  • 45 Principi T, Pantanetti S, Catani F. et al. Noninvasive continuous positive airway pressure delivered by helmet in hematological malignancy patients with hypoxemic acute respiratory failure. Intensive Care Med 2004; 30: 147-150
  • 46 Conti G, Cavaliere F, Costa R. et al. Noninvasive positive-pressure ventilation with different interfaces in patients with respiratory failure after abdominal surgery: a matched-control study. Respir Care 2007; 52: 1463-1471
  • 47 Adi O, Via G. Salleh. et al. Randomized clinical trial comparing helmet continuous positive airway pressure (hCPAP) to facemask continuous positive airway pressure (fCPAP) for the treatment of acute respiratory failure in the emergency department. Am J Emerg Med 2021; 49: 385-392
  • 48 Antonelli M, Pennisi MA, Pelosi P. et al. Noninvasive positive pressure ventilation using a helmet in patients with acute exacerbation of chronic obstructive pulmonary disease: a feasibility study. Anesthesiology 2004; 100: 16-24
  • 49 Navalesi P, Costa R, Ceriana P. et al. Non-invasive ventilation in chronic obstructive pulmonary disease patients: helmet versus facial mask. Int Care Med 2007; 33: 74-81
  • 50 Pankow W, Podszus T, Gutheil T. et al. Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity. J Appl Physiol (1985) 1998; 85: 1236-1243
  • 51 Grieco DL, Munshi L, Piquilloud L. Personalized noninvasive respiratory support for acute hypoxemic respiratory failure. Int Care Med 2023; 49: 840-843
  • 52 Duan J, Yang J, Jiang L. et al. Prediction of noninvasive ventilation failure using the ROX index in patients with de novo acute respiratory failure. Ann Intensive Care 2022; 12: 110
  • 53 Berg KM, Lang GR, Salciccioli JD. et al. The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure. Respir Care 2012; 57: 1548-1554
  • 54 Duan J, Han X, Bai L. Zhou. et al. Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients. Int Care Med 2017; 43: 192-199
  • 55 Grieco DL, Maggiore SM, Roca O. et al. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. Int Care Med 2021; 47: 851-866
  • 56 Lee CC, Mankodi D, Shaharyar S. et al. High flow nasal cannula versus conventional oxygen therapy and non-invasive ventilation in adults with acute hypoxemic respiratory failure: a systematic review. Respir Med 2016; 121: 100-108
  • 57 Mauri T, Turrini C, Eronia N. et al. Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure. Am J Respir Crit Care Med 2017; 195: 1207-1215
  • 58 Möller W, Celik G, Feng S. et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol 2015; 118: 1525-1532
  • 59 Luo J, Lu M, Zhao Z. et al. Positive end-expiratory pressure effect of 3 high-flow nasal cannula devices. Respir Care 2017; 62: 888-895
  • 60 Hardavella G, Karampinis I, Frille A. et al. Oxygen devices and delivery systems. Breathe 2019; 15: 108-116
  • 61 Frat JP, Thille AW, Mercat A. et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372: 2185-2196
  • 62 Rochwerg B., Granton D, Wang DX. et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019; 45: 563-572
  • 63 Lewis SR, Baker PE, Parker R. et al. High-flow nasal cannulae for respiratory support in adult intensive care patients. Cochrane Database Syst Rev 2021; (02) CD010172
  • 64 Simon M, Wachs C, Braune S. et al. High-flow nasal cannula versus bag-valve-mask for preoxygenation before intubation in subjects with hypoxemic respiratory failure. Respir Care 2016; 61: 1160-1167
  • 65 Cortegiani A, Longhini F, Madotto F. et al. High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial. Crit Care 2020; 24: 1-13
  • 66 Yang PL, Yi JQ, Chen HB. High-flow nasal cannula for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Heart Lung 2021; 50: 252-261
  • 67 Spoletini G, Mega C, Pisani L. et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: a pilot randomized controlled trial. J Crit Care 2018; 48: 418-425
  • 68 Rochwerg B, Einav S, Chaudhuri D. et al. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med 2020; 46: 2226-2237
  • 69 Hui DS, Chow BK, Lo T. et al. Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks. Eur Respir J 2019; 53: 1802339
  • 70 Wachs C, Grensemann J, Kluge S. High-Flow-Sauerstofftherapie–Schritt für Schritt. DMW-Deutsche Medizinische Wochenschrift 2020; 145: 693-697
  • 71 Roca O, Caralt B, Messika J. et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med 2019; 199: 1368-1376