Systemtherapie des Peniskarzinoms – neue Konzepte? Neue Erfolge?

Zusammenfassung

Die systemische Chemotherapie wird seit Jahren mit beim metastasierten Peniskarzinom angewandt, jedoch nur mit begrenztem Erfolg. Ihre Bedeutung liegt überwiegend im Rahmen der multimodalen Therapie bei lymphogener Metastasierung in Zusammenhang mit radikaler Lymphknotenchirurgie. Bei begrenztem Lymphknotenbefall kann die Kombination von operativer Therapie mit cisplatin- und taxanhaltigen Dreifachkombinationen kurativ sein.

Fortschritte im Verständnis der molekularen Veränderungen beim Peniskarzinom und die Suche nach potenziellen Therapietargets haben zur Auflegung zahlreicher Studien geführt. Trotz Hinweisen auf die Wirksamkeit von Immuntherapeutika haben sich bislang jedoch keine wesentlichen therapeutischen Verbesserungen für die klinische Praxis ergeben.

Abstract

Systemic chemotherapy has been in use for metastatic penile carcinoma for years, but its success is limited. Its significance is largely associated with its role in multimodal treatment for lymphatic metastasis in the context of radical lymph node surgery. In cases of limited lymph node involvement, the combination of surgical treatment plus cisplatin- and taxane-based triple combinations may be curative.

Advances in the understanding of molecular changes in penile cancer and the search for potential therapy targets have led to numerous studies. Although there is evidence of efficacy of immunotherapeutics, no significant therapeutic improvements have been seen in the clinical routine.

Schlüsselwörter

Peniskarzinom - Metastasen - Chemotherapie - Immuntherapie - Radiochemotherapie

Keywords

penile cancer - metastasis - chemotherapy - radiochemotherapy - immunotherapy

Publication History

Received: 03 May 2023

Accepted: 24 May 2023

Article published online:
02 February 2024

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