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DOI: 10.1055/a-2218-0237
Augenbeteiligung bei Graft-versus-Host-Erkrankung
Article in several languages: deutsch | English![](https://www.thieme-connect.de/media/klimo/202405/lookinside/thumbnails/10-1055-a-2218-0237_kl2958_de-1.jpg)
Zusammenfassung
Im Rahmen der okulären Graft-versus-Host-Erkrankung (GVHD) kommt es nach allogener hämatopoetischer Zelltransplantation zu einer Entzündungsreaktion an der Augenoberfläche. Verantwortlich hierfür sind insbesondere selbstreaktive T-Zellen des Spenders. Dies kann u. a. zu einer ausgeprägten Keratoconjunctivitis sicca, Bindehauthyperämie, Hornhautulzerationen und -einschmelzung bis hin zur Perforation führen. Die okuläre GVHD geht mit einem hohen Leidensdruck wie Schmerzen, Photophobie und Visusminderung einher. Diese Übersichtsarbeit gibt einen Überblick über typische ophthalmologische Befunde, topische und systemische Therapieansätze, begleitende Maßnahmen (z. B. Sklerallinsen, Punctum plugs) und das entsprechende Management von Komplikationen.
Schlüsselwörter
Graft-versus-Host-Erkrankung (GVHD) - allogene hämatopoetische Zelltransplantation (HCT) - Diagnose - Einteilung - TherapiePublication History
Received: 06 November 2023
Accepted: 21 November 2023
Article published online:
23 January 2024
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