Horm Metab Res 2024; 56(07): 477-481
DOI: 10.1055/a-2202-3894
Review

The Fate of Angiotensin II in Placental Tissue and Blood

Shigehiko Mizutani
1   Daiyabilding Lady’s Clinic, Nagoya, Japan
,
Hidesuke Mizutani
2   Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine Faculty of Medicine, Nagoya, Japan
,
Eita Mizutani
1   Daiyabilding Lady’s Clinic, Nagoya, Japan
,
Harumasa Arita
3   IP & License Strategy Division, Rohto Pharmaceutical Co.,Ltd., Osaka, Japan
,
Hiroaki Kajiyama
2   Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine Faculty of Medicine, Nagoya, Japan
› Author Affiliations

Abstract

The existence of a non-canonical pathway of renin-angiotensin system in the blood pressure control system has been highlighted over the past three decades. The enzymes involved in this pathway include a series of angiotensinases such as neprilysin (NEP), aminopeptidase A (APA), carboxypeptidase, and angiotensin converting enzyme 2. The physiological roles of these peptidases have been reconsidered in this study, based on the publications of other research groups and the results from our previous study, regarding the liberation of constituent amino acids from angiotensin II by placenta tissue and blood serum, respectively.



Publication History

Received: 19 September 2023

Accepted after revision: 01 November 2023

Accepted Manuscript online:
01 November 2023

Article published online:
11 December 2023

© 2023. Thieme. All rights reserved.

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