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DOI: 10.1055/a-2202-3894
The Fate of Angiotensin II in Placental Tissue and Blood
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Abstract
The existence of a non-canonical pathway of renin-angiotensin system in the blood pressure control system has been highlighted over the past three decades. The enzymes involved in this pathway include a series of angiotensinases such as neprilysin (NEP), aminopeptidase A (APA), carboxypeptidase, and angiotensin converting enzyme 2. The physiological roles of these peptidases have been reconsidered in this study, based on the publications of other research groups and the results from our previous study, regarding the liberation of constituent amino acids from angiotensin II by placenta tissue and blood serum, respectively.
Key words
pregnancy - hypertension - renin-angiotensin system - neprilysin - aminopeptidase A - angiotensin convertingenzymePublication History
Received: 19 September 2023
Accepted after revision: 01 November 2023
Accepted Manuscript online:
01 November 2023
Article published online:
11 December 2023
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