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Drug Res (Stuttg) 2024; 74(01): 5-17
DOI: 10.1055/a-2196-1815
Review

Dermaceutical Utilization of Nigella sativa Seeds: Applications and Opportunities

Mariyam Khatoon
1   Faculty of Pharmacy, Integral University, Lucknow, India
,
Poonam Kushwaha
1   Faculty of Pharmacy, Integral University, Lucknow, India
,
Shazia Usmani
1   Faculty of Pharmacy, Integral University, Lucknow, India
,
Kumud Madan
2   Sharda University, Greater Noida, Uttar Pradesh, India
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Abstract

Skin diseases have recently become a major concern among people of all ages due to their highly visible symptoms and persistent and difficult treatment, which significantly impact their quality of life. Nigella sativa seeds, also known as "black seeds" or "kalonji," are one of the most commonly used herbal medicines due to their wide range of biological and pharmacological activities. It contains a wide range of bioactive constituents found in both fixed and essential oils. It has been used for hundreds of years as an alternative ethnomedicine to treat a wide range of skin conditions. N. sativa's dermatological applications in skin diseases are attributed to its potent antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties, making it an intriguing skincare candidate. Several studies unravelled positive results associated with N. sativa on skin diseases. As N. sativa is the most studied medicinal plant, several preclinical and clinical studies have been conducted to establish its use in the treatment of various skin diseases. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to the treatment of skin diseases. In this context, the present review explores all the available studies on the association of N. sativa and its effect on treating skin diseases in light of recent studies and patents supporting its therapeutic applications.

Key words

Nigella sativa l - thymoquinone - skin diseases - toxicity - cosmeceutical applications - patent status


Publication History

Received: 04 August 2023

Accepted: 16 October 2023

Article published online:
28 November 2023

© 2023. Thieme. All rights reserved.

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